Current Clinical Trials
Retina Group of Florida is currently involved in multiple national clinical trials of the latest medical and surgical advances in retinal disease, including:
Active Trials (Closed to enrollment)
Wet Age-Related Macular Degeneration
A Phase 2b Study of Suprachoroidally Administered CLS-AX in Participants with Neovascular Age-Related Macular Degeneration
A Multi-Center, Randomized, Double-Masked Phase 2 Study to Assess Safety and Efficacy of ADVM-022 (AAV.7m8-aflibercept) in Anti-VEGF Treatment-Experienced Patients with Neovascular (Wet) Age-related Macular Degeneration (nAMD) [LUNA]
Dry Age-Related Macular Degeneration
A Phase 2, Multicenter, Randomized, Parallel-Group, Double-Masked, 4-Arm, Sham-Controlled Study of the Efficacy, Safety, and Tolerability of ANX007 Administered by Intravitreal Injection in Patients with Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD) - The ARCHER Study
An Open-label Extension (OLE) Phase 3 Trial to Assess the Safety of Intravitreal Administration of Avacincaptad Pegol (Complement C5 Inhibitor) in Patients With Geographic Atrophy Who Previously Completed Phase 3 Study ISEE2008 (GATHER2)
A Phase 2, Randomized Placebo-Controlled, Double-Masked Study to Assess Safety and Efficacy of Multiple Doses of IONIS-FB-LRx, an Antisense Inhibitor of Complement Factor B, in Patients with Geographic Atrophy Secondary to Age-Related Macular Degeneration
Diabetic Retinopathy
A Phase III, Multicenter, Randomized, Visual Assessor-Masked, Active-comparator Study of the Efficacy, Safety, and Pharmacokinetics of the Port Delivery System with Ranibizumab in Patients with Diabetic Macular Edema (Pagoda)
Faricimab for Retinal Non-Perfusion Associated With Non-Proliferative Diabetic Retinopathy: The MAGIC Phase 2, Multi-Center, Open-Label, Randomized Controlled Trial
Uveitis
Phase 4 Study of YUTIQ® (Fluocinolone Acetonide Intravitreal Implant) 0.18 mg in the Treatment of Chronic Non-Infectious Posterior Segment Uveitis (Intraocular Inflammation Study)
Diabetic Macular Edema
A Randomized, Double-Masked, Placebo-Controlled, Parallel-Arm Study to Evaluate the Efficacy and Safety of RZ402 in Participants With Diabetic Macular Edema (DME)
Active Enrolling Trials
Dry Age-Related Macular Degeneration
De-Centralized Prospective Epidemiological Study of Progression of Age-Related Macular Degeneration (AMD)
A Phase 2b, Randomized, Double-masked, Multicenter, Dose-ranging, Sham-controlled Clinical Trial to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)
A Multiple Dose Study of AVD-104 for Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration
Wet Age-Related Macular Degeneration
A Phase 3, Multicentre, Double-masked, Randomised Study to Evaluate the Efficacy and Safety of Intravitreal OPT-302 in Combination with Ranibizumab, Compared with Ranibizumab Alone, in Participants With nAMD
Home OCT-Guided Treatment Versus Treat and Extend for the Management of Neovascular AMD
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Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Ocular Therapeutix) (Axitinib Implant) in Subjects With Neovascular Age-Related Macular Degeneration
Safety and Effectiveness of ONS-5010 Compared to Lucentis® in Subjects With Neovascular Age-related Macular Degeneration
Uveitis
A Phase III, Multicenter, Randomized, Double-Masked, Sham-Controlled Study to Investigate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of RO7200220 Administered Intravitreally in Patients with Uveitic Macular Edema
Diabetic Retinopathy
A Randomized Clinical Trial Evaluating Fenofibrate for Prevention of Diabetic Retinopathy Worsening
Diabetic Macular Edema
Upcoming Trials
Diabetic Retinopathy
A Phase 2 randomized, placebo-controlled, double-masked, dose-finding study to investigate the efficacy and safety of BAY 3283142 in patients with moderately severe to severe nonproliferative diabetic retinopathy (ARGON-NPDR)
Completed Clinic Trials
Neovascular Age-Related Macular Degeneration (nAMD/wet AMD) with Persistent Retinal Fluid
Diabetic Macular Edema (DME)
Diabetic Macular Edema (DME)
Diabetic Macular Edema (DME)
Neovascular Age-Related Macular Degeneration (nAMD/wet AMD)
Macular Edema Secondary to Central Retinal (CRVO) or Hemiretinal Vein Occlusion (HRVO)
Macular Edema Secondary to Branch Retinal Vein Occlusion (BRVO)